Exercise training-induced regulation of mitochondrial quality.
نویسندگان
چکیده
Mitochondria are dynamic organelles in skeletal muscle critical in physical performance and disease. The mitochondrial life cycle spans biogenesis, maintenance, and clearance. Exercise training may promote each of these processes, conferring positive impacts on skeletal muscle contractile and metabolic functions. This review focuses on the regulation of these processes by endurance exercise and discusses potential benefits in health and disease.
منابع مشابه
The Effect of Six Weeks of Endurance Training on Mitochondrial Level of OPA-1 Quadriceps in Streptozotocin-induced Diabetic Rats
Introduction: Mitochondrial dynamic disorders are attributed to many diseases such as diabetes. MFN2 and OPA-1 proteins are the main regulators of fusion, and DRP1 is the essential protein regulating mitochondrial fission. Increasing or decreasing the expression of relevant genes will cause an imbalance between these two processes. This study evaluated the effect of six weeks of aerobic trainin...
متن کاملDecreased Uncoupling Protein 2 and 3 (UCP2 and UCP3) mRNA expression by endurance exercise training with and without chronic administration of nandrolone in rat heart
Introduction: The effect of regular exercise in decreasing the incidence of heart diseases is well known. The abuse of anabolic androgenic steroids (AAS) has been associated with cardiovascular disorders. Uncoupling proteins (UCPs) transport protons across the inner mitochondrial membrane thereby proton gradient can be diminished by the action of UCPs. This process will result in the uncoupl...
متن کاملEffect of 6 weeks of resistance exercise preconditioning on mitochondrial dynamics in cardiac tissue of diabetic rats
Background and Objectives: Diabetic cardiomyopathy refers to changes in the heart as a result of altered glucose homeostasis, leading to ventricular dysfunction, and it is associated with the mitochondrial abnormality. Since physical exercise has been known as cardioprotective, the aim of the present study was to investigate the effect of 6 weeks of resistance exercise preconditioning on mitoch...
متن کاملProtective Effect of Aerobic Training along with Resveratrol on Mitochondrial Dynamics of Cardiac Myocytes in Animal Model of Non-alcoholic Fatty Liver Disease
Background & objectives: Non-alcoholic fatty liver disease (NAFLD) is associated with mitochondrial dysfunction. The aim of the present study was to examine the effect of aerobic training along with resveratrol on cardiac expression of OPA1 and DRP1 in NAFLD male rats. Methods: In this experimental study, forty eight male Wistar rats were classified into two groups: NAFLD (n=40) and Control-N...
متن کاملExercise preconditioning: review
It is estimated that by 2035, more than 130 million adults will suffer from various types of cardiovascular diseases. Therefore, it is very important to know the pathogens of cardiac diseases and investigate new treatments. Also, despite continuous progress in diagnosis, patient education, and risk factor management, myocardial infarction (MI) remains one of the most common causes of morbidity,...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Exercise and sport sciences reviews
دوره 40 3 شماره
صفحات -
تاریخ انتشار 2012